correlational
Analysis v1
33
0
MOTS-c helps turn down genes linked to cell aging in pancreatic cells.
Scientific Claim
MOTS-c treatment in pancreatic islet cells is associated with downregulation of senescence-related genes Cd38 and Grem1.
Original Statement
“MOTS-c treatment significantly reduced the expression of Mdh1b, Grem1 and Cd38 in 60-week-old pancreatic islet cells (Fig. 4i).”
Evidence Quality Assessment
Claim Status
overstated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study used 'reduced' which implies causation, but the design lacks randomization/blinding confirmation. Corrected to 'associated with' to reflect observational association.
Evidence from Studies
Supporting (1)
33
33
Mitochondrial-encoded peptide MOTS-c prevents pancreatic islet cell senescence to delay diabetes
Randomized Controlled Trial
Human
2025 AugContradicting (0)
0
No contradicting evidence found