Old mice that got MOTS-c for a week had muscle glucose uptake as good as young mice, reversing age-related insulin resistance.

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Evidence from Studies

Supporting (1)

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The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance

Randomized Controlled Trial

Animal

2015 Mar 3

The study found that a molecule called MOTS-c helps older mice use insulin better to absorb sugar from their blood, similar to how young mice do—so it’s like giving older mice a metabolic boost to act more like younger ones.

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Source Study

The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance

Score: 13

DOI: 10.1016/j.cmet.2015.02.009

Similar Assertions

Old mice that got MOTS-c injections responded to insulin just as well as young mice, meaning the peptide might fix the insulin resistance that comes with aging.

76%

When mice were given a daily shot of a peptide called MOTS-c, their bodies became better at using sugar for energy and responding to insulin, especially in their muscles.

74%

Diabetic rats given MOTS-c had lower blood sugar levels after fasting, showing better control of glucose.

71%

After a week of MOTS-c injections, mice could process insulin better, needing 30% more glucose to keep blood sugar stable during a test.

71%