Obese women following a low-calorie diet for 10 weeks show reduced activity of the uncoupling protein 2 gene in their fat tissue, which affects how cells produce energy.

Scientific Claim

Energy restriction during a 10-week hypocaloric diet decreases uncoupling protein 2 mRNA expression in subcutaneous adipose tissue of obese women.

Original Statement

“Levels of peroxisome proliferator-activated receptor γ co-activator 1α mRNA were increased, while the expression of the genes encoding leptin, osteonectin, phosphodiesterase 3B, hormone-sensitive lipase, receptor A for natriuretic peptide, fatty acid translocase, lipoprotein lipase, uncoupling protein 2 and peroxisome proliferator-activated receptor γ was decreased.”

From study:Adipose tissue gene expression in obese subjects during low-fat and high-fat hypocaloric diets

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

definitive

Can make definitive causal claims

Assessment Explanation

The RCT design establishes causation for gene expression changes under hypocaloric conditions. The verb 'decreases' is appropriate for this causal claim.

Evidence from Studies

Supporting (1)

Adipose tissue gene expression in obese subjects during low-fat and high-fat hypocaloric diets

Randomized Controlled Trial

Human

2005 Jan

Contradicting (0)

No contradicting evidence found

Source Study

Adipose tissue gene expression in obese subjects during low-fat and high-fat hypocaloric diets

Score: 55

DOI: 10.1007/s00125-004-1618-x

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