Analysis Version
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History
Back to Study: Adipose tissue gene expression in obese subjects d...
causal
Analysis v1
55
Pro
0
Against

Obese women on a low-calorie diet for 10 weeks show reduced activity of the leptin gene in their fat tissue, which is linked to hunger regulation.

Scientific Claim

Energy restriction during a 10-week hypocaloric diet decreases leptin mRNA expression in subcutaneous adipose tissue of obese women.

Original Statement

“Levels of peroxisome proliferator-activated receptor γ co-activator 1α mRNA were increased, while the expression of the genes encoding leptin, osteonectin, phosphodiesterase 3B, hormone-sensitive lipase, receptor A for natriuretic peptide, fatty acid translocase, lipoprotein lipase, uncoupling protein 2 and peroxisome proliferator-activated receptor γ was decreased.”

From study:Adipose tissue gene expression in obese subjects during low-fat and high-fat hypocaloric diets

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

definitive

Can make definitive causal claims

Assessment Explanation

The RCT design establishes causation for gene expression changes under hypocaloric conditions. The verb 'decreases' is appropriate for this causal claim.

Evidence from Studies

Supporting (1)

55
55

Adipose tissue gene expression in obese subjects during low-fat and high-fat hypocaloric diets

Randomized Controlled Trial
Human
2005 Jan

Contradicting (0)

0
No contradicting evidence found

Source Study

Adipose tissue gene expression in obese subjects during low-fat and high-fat hypocaloric diets

Score: 55
DOI: 10.1007/s00125-004-1618-x

Similar Assertions

Obese women following a low-calorie diet for 10 weeks show reduced activity of the uncoupling protein 2 gene in their fat tissue, which affects how cells produce energy.

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85%

Obese women on a low-calorie diet for 10 weeks show reduced activity of the hormone-sensitive lipase gene in their fat tissue, which affects how fat is broken down.

55
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84%

Obese women following a low-calorie diet for 10 weeks show reduced activity of the osteonectin gene in their fat tissue, which is involved in tissue structure and fat storage.

55
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83%

When obese women lose weight on a low-calorie diet, the activity of the lipoprotein lipase gene in fat tissue goes down, which affects how fats are stored in cells.

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83%

When obese women follow a low-calorie diet for 10 weeks, the activity of the natriuretic peptide receptor gene in fat tissue decreases, which affects how fat cells respond to certain hormones.

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82%