People with HIV and belly fat who responded to tesamorelin by losing belly fat saw their rectus and psoas muscles grow 0.44 cm² and 0.46 cm² larger than those on placebo after 26 weeks of treatment.

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Evidence from Studies

Supporting (1)

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The Growth Hormone Releasing Hormone Analogue, Tesamorelin, Decreases Muscle Fat and Increases Muscle Area in Adults with HIV

Randomized Controlled Trial

Human

2019

The study found that a drug called tesamorelin helped HIV-positive people with belly fat lose that fat and also gain a little more muscle in their abdomen and lower back compared to those who didn’t take the drug.

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No contradicting evidence found

Source Study

The Growth Hormone Releasing Hormone Analogue, Tesamorelin, Decreases Muscle Fat and Increases Muscle Area in Adults with HIV

Score: 60

DOI: 10.14283/jfa.2018.45

Similar Assertions

People with HIV and belly fat who responded to tesamorelin by losing belly fat saw their trunk muscles grow larger in specific areas: rectus abdominis by 0.85 cm², psoas by 0.64 cm², and others by up to 1.08 cm² more than those on placebo after 26 weeks.

95%

HIV patients with belly fat who responded to tesamorelin had bigger rectus and psoas muscles (0.44 and 0.46 cm² larger) compared to placebo after 26 weeks.

95%

The drug made two key core muscles—rectus and psoas—slightly bigger, adding about half a square inch each after six months, while the placebo group didn’t change.

94%

Tesamorelin increased rectus and psoas muscle size by 0.44 and 0.46 cm² in people with HIV and belly fat, and this effect remained even after accounting for belly fat loss.

94%

For people with HIV and belly fat who responded to tesamorelin by losing belly fat, taking the drug for 26 weeks made their trunk muscles denser by 1.56 to 4.86 units compared to those who didn't take it.

90%