People who are obese, have type 2 diabetes, and a certain kind of heart failure might lose over 10% of their body weight if they take a weekly shot called semaglutide, and this could help calm heart inflammation and make them feel better overall.

Taking a weekly semaglutide shot (2.4 mg) might help obese adults with a certain type of heart failure feel better and move more easily, based on patient-reported quality of life scores.

A weekly 2.4 mg dose of semaglutide seems to cut inflammation by nearly half in obese adults with a certain type of heart failure — and that might help them feel better and live longer.

Even if you don’t have diabetes, if you’re overweight and have heart disease, a weekly shot of semaglutide can cut your risk of heart attack or stroke by 1 in 5 — and this benefit starts before you lose much weight.

Taking a weekly semaglutide shot (2.4 mg) for about a year and a half can help lower blood pressure, blood sugar, bad cholesterol, and body-wide inflammation in adults with extra weight but no diabetes—better than a placebo.

For adults who aren't diabetic but carry extra weight, a weekly injection of semaglutide (2.4 mg) plus healthy lifestyle changes led to nearly 15% weight loss over a year and a half—way more than lifestyle changes alone.