Activation of PPARα increases the expression of CPT-1, CPT-2, and CD36, which enhances the transport of fatty acids into mitochondria and promotes β-oxidation.

Study: PPARα agonist fenofibrate prevents postoperative cognitive dysfunction by enhancing fatty acid oxidation in mice

The study shows that turning on a protein called PPARα with a drug increases levels of other proteins that help burn fat for energy in cells, which supports the idea that PPARα helps move fatty acids into energy factories in cells.

Study: PPARα agonist fenofibrate enhances fatty acid β-oxidation and attenuates polycystic kidney and liver disease in mice.

The study used a drug that turns on a protein called PPARα, and found it helped the body burn fat more efficiently, which supports the idea that activating this protein helps move fat into energy factories in cells.

Study: Acetic Acid Influences BRL-3A Cell Lipid Metabolism via the AMPK Signalling Pathway

The study shows that acetic acid turns on a cellular switch (AMPK) that boosts a fat-burning pathway involving PPARα, which supports the idea that activating PPARα helps burn fat in liver cells.