Turning on a protein called PPARα helps cells move fat into tiny energy factories (mitochondria) so it can be burned for fuel.

Pro

Against

Evidence from Studies

Supporting (3)

Community contributions welcome

PPARα agonist fenofibrate prevents postoperative cognitive dysfunction by enhancing fatty acid oxidation in mice

Randomized Controlled Trial

Animal & In Vitro

2023 Jan 1

PPARα agonist fenofibrate enhances fatty acid β-oxidation and attenuates polycystic kidney and liver disease in mice.

Randomized Controlled Trial

Animal

2018 Jan 1

Acetic Acid Influences BRL-3A Cell Lipid Metabolism via the AMPK Signalling Pathway

Cross-Sectional Study

In Vitro

1979 Apr

Contradicting (1)

Community contributions welcome

Exposure to short-chain chlorinated paraffins inhibited PPARα-mediated fatty acid oxidation and stimulated aerobic glycolysis in vitro in human cells.

Cross-Sectional Study

In Vitro

2021 Jun 10

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Similar Assertions

Your body needs to keep turning on a protein called PPARα for a long time to grow more energy factories in your cells and get better at burning fat over the long haul.

83%

Acetic acid might help liver cells burn fat better by turning on certain fat-burning genes, especially when used at a specific amount in lab studies.

73%

Treating rat liver cells with low doses of acetic acid boosts genes and proteins that help burn fat, suggesting these cells might get better at breaking down fats.

72%

Fructose turns down the liver’s main switch (PPARα) that tells the body to burn fat, and it also reduces the level of a critical enzyme (CPT1α) needed to get fat into the mitochondria to be burned.

72%