Can a diabetes-like medicine help shrink kidney and liver cysts in mice?
PPARα agonist fenofibrate enhances fatty acid β-oxidation and attenuates polycystic kidney and liver disease in mice.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists gave a drug called fenofibrate to mice with kidney and liver cysts to see if it helped. The drug turns on a switch in cells that helps burn fat for energy.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
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Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists gave a drug called fenofibrate to mice with kidney and liver cysts to see if it helped. The drug turns on a switch in cells that helps burn fat for energy.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 512 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Publication
Authors
Lakhia R, Yheskel M, Flaten A, Quittner-Strom EB, Holland WL, Patel V
Related Content
Claims (5)
Turning on a protein called PPARα helps cells move fat into tiny energy factories (mitochondria) so it can be burned for fuel.
In mice with a kidney disease similar to one in humans, giving them a drug called fenofibrate seems to boost the activity of genes that help burn fat for energy in the kidneys, which might mean their kidney cells are using energy more efficiently.
Fenofibrate seems to slow down kidney disease in mice with a condition similar to polycystic kidney disease, making their kidneys healthier after five months of treatment.
In mice with a genetic form of kidney disease, taking a drug called fenofibrate seems to slow down the growth of kidney cysts and reduce harmful inflammation in the kidneys.
Fenofibrate, a drug that changes how the liver processes energy, seems to help reduce liver cysts and damage in a type of mouse with a genetic liver disease.