Taking Premarin for hormone therapy might make you more likely to get dangerous blood clots than taking a different type of estrogen called bio-identical estradiol.

55

Pro

0

Against

Evidence from Studies

Supporting (1)

55

Community contributions welcome

55

Esterified estrogens and conjugated equine estrogens and the risk of venous thrombosis.

Case-Control Study

Human

2004 Oct 6

This study found that Premarin (a horse-derived estrogen) increases the risk of blood clots more than another type of estrogen called esterified estrogens. While it didn’t test pure human-like estradiol, it still suggests that horse-based hormones are riskier than other kinds, which supports the claim.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Similar Assertions

Women who are going through or have passed menopause and are taking a specific type of hormone pill called conjugated equine estrogen are 65% more likely to have their first blood clot in a vein than women who aren’t taking any hormones.

55

0

82%

Women who take a type of hormone therapy called conjugated equine estrogen are 78% more likely to develop blood clots in their veins than women who take a different type called esterified estrogen.

55

0

80%

Women who take higher doses of this hormone medicine called conjugated equine estrogen are more likely to develop blood clots in their veins.

55

0

80%

Some women take hormones to manage menopause symptoms, and this claim says that a type of estrogen made to match the body’s own (bio-identical estradiol) is safer for blood clots than a different type made from horse urine (conjugated equine estrogens).

1

0

79%