Rats using regular antibacterial mouthwash had lower antioxidant protection in their blood after one week, while rats using the special nitrate mouthwash didn't see this change, showing different effects on the body's antioxidant system.
Scientific Claim
Wistar rats using a chlorhexidine-based mouth rinse showed significant reductions in serum hydrophilic and total antioxidant capacity compared to baseline, while the nitrate-containing mouth rinse group maintained stable antioxidant levels, suggesting differential effects on redox status.
Original Statement
“There was a significant reduction in serum hydrophilic and total AC by 14.8% (p = 0.012) and 16.0% (p = 0.038), respectively, in the CHX rinse group after one week of intervention. No significant changes in serum antioxidant capacity measures were observed in the bioactive rinse group.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study is an animal model showing association between mouth rinse type and changes in antioxidant capacity. The verb 'showed significant reductions' is appropriate for this quantitative finding in an animal study.
More Accurate Statement
“Wistar rats using a chlorhexidine-based mouth rinse were associated with significant reductions in serum hydrophilic and total antioxidant capacity compared to baseline, while the nitrate-containing mouth rinse group maintained stable antioxidant levels, suggesting differential effects on redox status.”
Evidence from Studies
Supporting (1)
Functional mouth rinse containing inorganic nitrate and antioxidants bolsters the enterosalivary pathway and lowers blood pressure in Wistar rats