A special mouthwash with nitrate and antioxidants made rats' blood nitrate levels jump 32 times higher than regular mouthwash after one week, which might help their heart health.
Scientific Claim
A mouth rinse containing inorganic nitrate and antioxidants significantly increased blood nitrate levels by 32.4-fold compared to a chlorhexidine-based mouth rinse in Wistar rats after one week of intervention, suggesting enhanced nitrate bioavailability for potential cardiovascular benefits.
Original Statement
“In contrast, significant alterations were observed in the bioactive rinse group such that blood and salivary nitrate increased by 32.4-fold (p < 0.001) and 5.7-fold (p = 0.004), respectively, after one week of intervention.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study is an animal model with a control group, showing association between the mouth rinse and increased nitrate levels. The verb 'increased' is appropriate for this quantitative finding in an animal study.
More Accurate Statement
“A mouth rinse containing inorganic nitrate and antioxidants was associated with a 32.4-fold increase in blood nitrate levels compared to a chlorhexidine-based mouth rinse in Wistar rats after one week of intervention, suggesting enhanced nitrate bioavailability for potential cardiovascular benefits.”
Evidence from Studies
Supporting (1)
Functional mouth rinse containing inorganic nitrate and antioxidants bolsters the enterosalivary pathway and lowers blood pressure in Wistar rats