The special mouthwash made rats' saliva have 5.7 times more nitrate and 6.3 times more nitrite than regular mouthwash, which helps the body's natural blood pressure regulation system.
Scientific Claim
A nitrate-containing mouth rinse significantly increased salivary nitrate levels by 5.7-fold and salivary nitrite levels by 6.3-fold compared to chlorhexidine mouth rinse in Wistar rats, supporting the activation of the enterosalivary pathway.
Original Statement
“Salivary nitrate and nitrite concentrations were also significantly greater in the bioactive rinse group compared to the CHX rinse group (p = 0.003, p = 0.017, respectively, Fig. 2).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study is an animal model showing association between the mouth rinse and increased salivary nitrate/nitrite levels. The verb 'increased' is appropriate for this quantitative finding in an animal study.
More Accurate Statement
“A nitrate-containing mouth rinse was associated with a 5.7-fold increase in salivary nitrate levels and 6.3-fold increase in salivary nitrite levels compared to chlorhexidine mouth rinse in Wistar rats, supporting the activation of the enterosalivary pathway.”
Evidence from Studies
Supporting (1)
Functional mouth rinse containing inorganic nitrate and antioxidants bolsters the enterosalivary pathway and lowers blood pressure in Wistar rats