Rats using the special mouthwash had more good bacteria in their mouths that help convert nitrate to nitric oxide, compared to rats using regular mouthwash.
Scientific Claim
Wistar rats using a nitrate-containing mouth rinse showed significantly greater relative abundance of nitrate-reducing bacteria (Veillonella, Haemophilus, and Staphylococcus) compared to chlorhexidine mouth rinse, suggesting microbiome modulation to support nitric oxide production.
Original Statement
“Kruskal–Wallis analysis revealed that the bioactive rinse group had significantly greater (p < 0.05) mean relative abundance of genera with established nitrate- or nitrite-reducing capabilities compared to the CHX rinse group, including Veilloneilla (CHX: 0.38%, Bioactive: 1.05%), Haemophilus (CHX: 0.05%, Bioactive: 0.11%), and Staphylococcus (CHX: 0.94%, Bioactive: 1.49%).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study is an animal model showing association between the mouth rinse and changes in bacterial abundance. The verb 'showed' is appropriate for this descriptive finding in an animal study.
More Accurate Statement
“Wistar rats using a nitrate-containing mouth rinse were associated with significantly greater relative abundance of nitrate-reducing bacteria (Veillonella, Haemophilus, and Staphylococcus) compared to chlorhexidine mouth rinse, suggesting microbiome modulation to support nitric oxide production.”
Evidence from Studies
Supporting (1)
Functional mouth rinse containing inorganic nitrate and antioxidants bolsters the enterosalivary pathway and lowers blood pressure in Wistar rats