Researchers gave women a drink with 400 mg of nitrate (from beetroot juice) to see how it affected their blood pressure and nitrate/nitrite levels.

Scientific Claim

Dietary nitrate supplementation (400 mg in beetroot juice) was administered to women with or without hypertension to measure changes in blood pressure and nitrate/nitrite levels.

Original Statement

“Following an overnight fast, plasma, saliva and tongue scraping samples were collected for measurement of nitrate/nitrite concentrations, oral nitrate-reductase (NaR) activity and microbiota profiling using 16S rRNA gene sequencing. Baseline BP was measured, followed by the administration of a single dose of dietary nitrate (400mg nitrate in 70mL beetroot juice). Post-nitrate intervention, plasma and salivary nitrate/nitrite concentrations and BP were determined 2.5 hours later.”

From study:Altered Oral Nitrate Reduction and Bacterial Profiles in Hypertensive Women Predict Blood Pressure Lowering Following Acute Dietary Nitrate Supplementation

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study describes the intervention method without making causal claims. The language 'was administered' appropriately describes the study procedure.

Evidence from Studies

Supporting (1)

Altered Oral Nitrate Reduction and Bacterial Profiles in Hypertensive Women Predict Blood Pressure Lowering Following Acute Dietary Nitrate Supplementation

Cross-Sectional Study

Human

2023 Nov

Contradicting (0)

No contradicting evidence found

Source Study

Altered Oral Nitrate Reduction and Bacterial Profiles in Hypertensive Women Predict Blood Pressure Lowering Following Acute Dietary Nitrate Supplementation

Score: 34

DOI: 10.1161/HYPERTENSIONAHA.123.21263

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