Taking a supplement called nicotinamide riboside for six weeks might change how certain genes work in people with moderate to severe kidney disease, possibly helping with energy and metabolism.

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Pro

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Against

Evidence from Studies

Supporting (1)

72

Community contributions welcome

72

A Pilot Trial of Nicotinamide Riboside and Coenzyme Q10 on Inflammation and Oxidative Stress in CKD

Randomized Controlled Trial

Human

2025 Mar 1

The study gave people with kidney disease 1000 mg of nicotinamide riboside daily for 6 weeks and found it changed genes related to energy, fat, and immune function, which supports the idea that it could help with metabolism.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

A Pilot Trial of Nicotinamide Riboside and Coenzyme Q10 on Inflammation and Oxidative Stress in CKD

Score: 72

DOI: 10.2215/CJN.0000000624

Similar Assertions

Taking a supplement called nicotinamide riboside for six weeks might change how genes work in the blood of people with moderate to severe kidney disease, possibly affecting how the body handles sugar, fat, and the immune system.

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Taking a supplement called nicotinamide riboside for six weeks might help immune cells in people with kidney disease work better by boosting their energy levels.

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86%

In people with moderate to severe kidney disease, taking either nicotinamide riboside or coenzyme Q10 for six weeks seems to change how certain genes work in the blood — one affects energy and fat processing, while the other influences immunity and stress, suggesting they work in different ways.

72

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84%

Taking a supplement called nicotinamide riboside for six weeks might help immune cells in people with serious kidney disease work better by boosting their energy levels.

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83%

In people with moderate to severe kidney disease, taking 1000 mg of nicotinamide riboside daily for six weeks may boost energy in immune cells, but the same doesn’t happen with a high dose of CoQ10.

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82%