Taking GlyNAC for 16 weeks helped older adults have lower blood pressure compared to before they started taking it.
Scientific Claim
GlyNAC supplementation for 16 weeks in older adults was associated with improvements in blood pressure metrics including systolic blood pressure compared to baseline measurements.
Evidence Quality Assessment
Claim Status
overstated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study claims 'improved/corrected these defects' which implies causation. However, the study design has unclear blinding, making it a Level 2b evidence (cohort-level) rather than RCT-level evidence. Therefore, 'improved' should be replaced with 'associated with improvements' to reflect the association rather than causation.
Source Excerpt
“Compared to YA, OA had GSH deficiency, OxS, mitochondrial dysfunction (with defective molecular regulation), inflammation, endothelial dysfunction, IR, multiple aging hallmarks, impaired physical function, increased waist circumference, and systolic blood pressure. GlyNAC (and not placebo) supplementation in OA improved/corrected these defects.”