Taking melatonin supplements might help lower high blood pressure at night and improve overall blood pressure readings in people with heart conditions. This effect seems to happen because melatonin could help relax blood vessels and calm the nervous system.

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Evidence from Studies

Supporting (1)

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Community contributions welcome

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Chronobiotic and cytoprotective activity of melatonin in the cardiovascular system. Doses matter

Narrative Review

Human

2024 Sep 9

Taking melatonin helps lower high blood pressure at night and improves overall heart health in people with heart conditions by calming the nervous system and protecting blood vessels.

Contradicting (0)

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Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Chronobiotic and cytoprotective activity of melatonin in the cardiovascular system. Doses matter

Score: 1

DOI: 10.1038/s44323-024-00007-z

Science Topic

Does melatonin lower nighttime blood pressure in heart disease patients?

Supported

Melatonin & Blood Pressure

What we've found so far suggests that melatonin might help lower nighttime blood pressure in people with heart conditions. The evidence we've reviewed suggests a possible benefit. Our current analysis shows that 1 study supports this idea, while 0 studies refute it. The research we looked at indicates that taking melatonin supplements could improve overall blood pressure readings during the night. This effect appears to happen because melatonin may help relax the walls of your blood vessels [1]. It might also calm your nervous system, which is the network of nerves that controls your body functions. When your blood vessels relax and your nervous system settles, your blood pressure can drop. We want to be clear that this is only a partial view. Our analysis is based on a single assertion right now. The evidence we've reviewed leans toward a positive effect, but we do not have enough data to say how strong that effect is. We will keep tracking new research as it comes in. Our current analysis shows a promising direction, but the picture is still incomplete. If you have heart disease and are wondering about melatonin, talk to your doctor before starting any supplement. You can ask whether taking it at night might fit safely into your current care plan. Keep monitoring your blood pressure as usual, and share any changes with your healthcare provider.

2 items of evidenceView full answer

Similar Assertions

Taking melatonin supplements might slightly lower your top blood pressure number by about 2 points. However, how much it actually helps depends on your starting blood pressure and other personal health factors, so the real-world benefit isn't the same for everyone.

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Taking melatonin supplements may lower your blood pressure, blood sugar, and bad cholesterol, while also reducing inflammation and boosting your body's natural antioxidants.

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Taking melatonin supplements can help lower high blood pressure, especially at night, by improving blood vessel function and balancing the body's natural sleep-wake rhythms. This is particularly helpful for people who don't normally see their blood pressure drop at night or those with metabolic syndrome, potentially protecting their heart and blood vessels over the long term.

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Taking melatonin supplements seems to help your body's relaxation system work better, which shows up as a healthier heart rate pattern, especially when you're resting or sleeping. This effect is seen in both healthy people and those with heart or brain conditions.

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People with heart disease, metabolic issues, or sleep problems often have lower levels of melatonin, the body's natural sleep hormone. This drop might be caused by aging, poor sleep cycles, or long-term inflammation, and boosting melatonin back to normal levels could potentially help slow down these health conditions.

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