Scientists gave male mice a compound called 17-alpha-estradiol at different ages and found that mice treated at 16 months lived about 7% longer than untreated mice, but mice treated later at 20 months only lived about 5% longer - and that result might just be due to chance.

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Against

Evidence from Studies

Supporting (1)

13

Community contributions welcome

13

17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex

Cohort Study

Animal

2021 May

The study directly confirms what the claim says - male mice given 17-alpha-estradiol at 16 months lived 7% longer at the 90th percentile (with strong statistical support), while those started at 20 months showed only 5% improvement that wasn't statistically meaningful.

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex

Score: 13

DOI: 10.1111/acel.13328

Similar Assertions

Giving male mice a special compound called 17-α-estradiol when they were middle-aged (16 months) helped them live about 7% longer, specifically extending their maximum lifespan.

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95%

A special form of estrogen called 17-alpha-estradiol helped male mice live longer when they started taking it in middle age - about 19% longer if started at 16 months old and 11% longer if started at 20 months old. It also increased their maximum lifespan by 7%. But female mice didn't get any lifespan benefit from it at all.

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92%

Scientists gave old mice a compound called 17-alpha-estradiol when they were already pretty old (like 50-60 human years), and it still made them live 11% longer on average.

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90%

A special form of estrogen called 17-alpha-estradiol helped male mice live longer, but female mice given the same amount didn't get any lifespan benefit.

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86%

Scientists gave old male mice a special compound called 17-alpha-estradiol when they were about 1.3 years old, and it helped them live about 19% longer - going from an average of about 2 years to over 2.5 years.

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85%