Analysis Version
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History
Back to Study: Association Between Nitrate‐Reducing Oral Bacteria...
correlational
53
Pro
0
Against

The link between oral bacteria that convert nitrates to nitrites and blood pressure is stronger in people who don't have high blood pressure already.

Scientific Claim

The relationship between nitrate-reducing oral bacteria and systolic blood pressure is stronger in individuals without hypertension compared to the general population.

Original Statement

“NO3TSS was associated with systolic BP only among patients without hypertension; 1-SD increase in NO3TSS was associated with −1.53 (95% CI, −2.82 to −0.24) mm Hg lower mean systolic BP.”

From study:Association Between Nitrate‐Reducing Oral Bacteria and Cardiometabolic Outcomes: Results From ORIGINS

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study is observational and cross-sectional, so 'associated with' is the correct verb strength. The claim accurately reflects the statistical relationship without implying causation.

Evidence from Studies

Supporting (1)

53
53

Association Between Nitrate‐Reducing Oral Bacteria and Cardiometabolic Outcomes: Results From ORIGINS

Cross-Sectional Study
Human
2019 Dec 3

Contradicting (0)

0
No contradicting evidence found

Source Study

Association Between Nitrate‐Reducing Oral Bacteria and Cardiometabolic Outcomes: Results From ORIGINS

Score: 53
DOI: 10.1161/JAHA.119.013324

Similar Assertions

People with more oral bacteria that convert nitrates to nitrites tend to have lower blood pressure, but only if they don't already have high blood pressure.

53
0
94%

The small blood pressure increase from using the special mouthwash was similar in size to what's known to increase the risk of heart disease and stroke.

45
0
88%

When nitrite levels in the blood went down after using mouthwash, blood pressure went up, and this connection was strong enough to be statistically significant.

45
0
88%

When people used the special mouthwash, their blood pressure went up but their heart rate didn't change, which suggests the effect is specific to blood pressure regulation.

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87%

When bacteria that help convert nitrate to nitrite in the mouth are reduced, blood pressure tends to go up by a small amount (2-3.5 mmHg for systolic and 2-2.2 mmHg for diastolic).

45
0
87%