These two harmful trans fats cause blood vessel cells to produce excess harmful oxygen molecules, which then trigger inflammation and block the production of a key chemical that keeps blood vessels healthy.

6

Pro

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Against

Evidence from Studies

Supporting (1)

6

Community contributions welcome

6

Trans Fatty Acids Induce Vascular Inflammation and Reduce Vascular Nitric Oxide Production in Endothelial Cells

Cross-Sectional Study

In Vitro

2011

The study found that two unhealthy fats (elaidic and linoelaidic acid) make blood vessel cells produce more harmful free radicals (superoxide), which in turn triggers inflammation and reduces a protective molecule (nitric oxide). This matches the claim that these fats work through superoxide to cause damage.

Contradicting (0)

0

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Trans Fatty Acids Induce Vascular Inflammation and Reduce Vascular Nitric Oxide Production in Endothelial Cells

Score: 6

DOI: 10.1371/journal.pone.0029600

Similar Assertions

Two types of artificial trans fats found in fried and baked foods make blood vessel cells more inflamed and less able to produce a chemical that helps blood vessels relax, but a different trans fat found in dairy doesn’t do this.

6

0

77%

Where the ‘kink’ is in the fat molecule decides whether it harms blood vessels — a kink at position 9 or 9+12 is bad, but at position 11 is harmless.

6

0

72%