When cow liver cells are exposed to certain levels of a substance called acetate, it seems to turn down the activity of genes that tell the cell to make fat — and this might happen through a specific cellular switch called AMPK.

11

Pro

0

Against

Evidence from Studies

Supporting (1)

11

Community contributions welcome

11

Acetic Acid Activates the AMP-Activated Protein Kinase Signaling Pathway to Regulate Lipid Metabolism in Bovine Hepatocytes

Cross-Sectional Study

Animal

2013

The study shows that acetate reduces fat-making genes in cow liver cells by turning on a switch called AMPK, and this effect goes away if you block that switch—just like the claim says.

Contradicting (0)

0

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Acetic Acid Activates the AMP-Activated Protein Kinase Signaling Pathway to Regulate Lipid Metabolism in Bovine Hepatocytes

Score: 11

DOI: 10.1371/journal.pone.0067880

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