When obese women follow a low-calorie diet for 10 weeks, the activity of the PGC-1α gene in their fat tissue increases, which helps regulate energy use in cells.

When obese women lose weight on a low-calorie diet, the activity of the PPARγ gene in fat tissue goes down, which affects how fat cells develop and store fat.

Obese women following a low-calorie diet for 10 weeks show reduced activity of the uncoupling protein 2 gene in their fat tissue, which affects how cells produce energy.

Obese women on a low-calorie diet for 10 weeks show reduced activity of the hormone-sensitive lipase gene in their fat tissue, which affects how fat is broken down.

When obese women lose weight on a low-calorie diet, the activity of the lipoprotein lipase gene in fat tissue goes down, which affects how fats are stored in cells.

Obese women following a low-calorie diet for 10 weeks show reduced activity of the osteonectin gene in their fat tissue, which is involved in tissue structure and fat storage.