When the fat tissue was given serotonin (a chemical the body uses in mood and digestion), it made over twice as many harmful molecules — but adding methylene blue cut that increase in half, showing the enzyme MAO-A is involved.

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Evidence from Studies

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Methylene blue reduces monoamine oxidase expression and oxidative stress in human cardiovascular adipose tissue

Cross-Sectional Study

Human

2025 Apr

The study found that adding serotonin to fat tissue around the heart makes it produce more harmful chemicals, and adding a substance called methylene blue reduces that effect — which means serotonin’s damage is partly caused by a specific enzyme that methylene blue can block.

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No contradicting evidence found

Source Study

Methylene blue reduces monoamine oxidase expression and oxidative stress in human cardiovascular adipose tissue

Score: 33

DOI: 10.1007/s11010-024-05092-z

Similar Assertions

When the fat tissue was given serotonin (a chemical that MAO-A breaks down), it made more harmful molecules—but adding methylene blue stopped some of that increase.

95%

When fat tissue around the heart and blood vessels was soaked in a blue dye called methylene blue for a day in the lab, it made less of a harmful enzyme and produced fewer damaging chemicals, which might help explain how the dye could protect cells.

80%

When fat tissue around the heart and blood vessels from heart failure patients was soaked in a small amount of methylene blue for a day, the levels of a specific enzyme (MAO-A) that makes harmful molecules went down.

72%