The Claim
In rat L6 myoblasts, knockdown of the vitamin D receptor (VDR) reduces Myh7 gene expression to 37%, 29%, and 43% of control levels at 0 pM, 1 pM, and 10 pM 1,25-dihydroxyvitamin D3, respectively, but Myh7 expression is restored to control levels at 100 pM 1,25-dihydroxyvitamin D3.
What the research says
Roughly balanced
Support and challenge are close. The picture may shift as more studies come in.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
When scientists reduced a specific vitamin D sensor in rat muscle cells, the cells made less of a protein linked to slow-twitch muscles—unless they added a lot of vitamin D, then the protein came back.
See the scientific wording
In rat L6 myoblasts, knockdown of the vitamin D receptor (VDR) suppresses Myh7 gene expression (slow-twitch fiber marker) to 37%, 29%, and 43% of control levels at 0 pM, 1 pM, and 10 pM 1,25-dihydroxyvitamin D3, respectively, but expression is restored at 100 pM.
What the research says
1 studyStudy: 1,25‐Dihydroxyvitamin D3 Mediates L6 Myoblast Differentiation via Vitamin D Receptor (VDR)
Scientists turned down the vitamin D receptor in rat muscle cells and saw that a slow-twitch muscle gene (Myh7) got weaker — unless they gave a high dose of vitamin D, which brought the gene back to normal. This matches exactly what the claim says.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.