Whether people have certain common gene versions doesn’t change how much their bad cholesterol drops when they eat high-glucoraphanin broccoli.
Scientific Claim
The LDL cholesterol-lowering effect of high glucoraphanin broccoli is not influenced by APOE, GSTM1, or PAPOLG genetic variants in middle-aged adults at moderate cardiovascular risk.
Original Statement
“There was no significant association between reduction in LDL-C and... APOE genotype (p = 0.909), PAPOLG genotype (p = 0.574), or GSTM1 genotype (p = 0.653).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
The RCT included genetic subgroup analysis with appropriate statistical tests (ANOVA). The null results are clearly reported with p-values, supporting definitive language.
Evidence from Studies
Supporting (0)
Contradicting (1)
Diet rich in high glucoraphanin broccoli reduces plasma LDL cholesterol: Evidence from randomised controlled trials
The study shows that eating a special kind of broccoli lowers bad cholesterol, but it didn’t check if people’s genes affect how well it works — so we can’t say whether genes matter or not.