Eating large amounts of phytate, a compound found in some plant foods, might reduce how much zinc the body absorbs in the short term under controlled lab conditions, but this does not necessarily...
Mechanism
Synthesis from 1 study
Phytate in food binds to zinc in the gut and makes it impossible for the body to absorb. The zinc then exits the body in stool instead of entering the bloodstream. This can lower zinc levels in the body, but only if phytate is eaten in large amounts without enough zinc or other nutrients that help...
Most probable mechanism
When phytate is eaten with zinc-rich foods, it binds tightly to zinc in the gut, forming a solid compound that the body cannot absorb. This trapped zinc passes through the intestines and leaves the body in stool, leaving less zinc available for use by tissues and organs.
Phytate dissociates in the intestinal lumen and binds to free zinc ions, forming an insoluble complex at physiological pH.
The phytate-zinc complex cannot be transported across the apical membrane of intestinal enterocytes due to its insolubility and lack of affinity for zinc transporters.
Reduced zinc uptake by enterocytes leads to decreased delivery of zinc into the bloodstream and lower systemic zinc availability.
Systemic zinc deficiency is reflected in reduced urinary zinc excretion and increased fecal zinc excretion due to unabsorbed zinc passing through the digestive tract.
Evidence from Studies
Supporting (1)
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A stable isotope study of zinc absorption in young men: effects of phytate and alpha-cellulose.
Contradicting (0)
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