Browse evidence-based analysis of health-related claims and assertions
MOTS-c didn't affect the triglyceride levels in the muscles of immobilized mice, even though it reduced fatty acids.
Mice with higher levels of MOTS-c in their muscles tended to have more muscle mass after immobilization.
MOTS-c changed the activity of genes involved in fat metabolism in the muscles of immobilized mice.
Mice given MOTS-c had more ANGPTL4 protein in their muscles and less fatty acids, which may help prevent muscle damage from fat buildup.
MOTS-c treatment lowered levels of myostatin, a protein that normally limits muscle growth, in immobilized mice.
MOTS-c helped restore normal activity levels of key muscle proteins (AKT and FOXOs) that are disrupted during immobilization.
Mice with immobilized legs that received MOTS-c had lower levels of key inflammation markers in their blood compared to untreated mice.
When mice had their legs immobilized for 8 days, giving them MOTS-c daily helped their muscles lose less weight—only 5% compared to 15% without treatment.
Using multiple weight-loss methods together works better and faster than just one method alone. This finding is from the abstract summary - full study details were not available
Eating more protein instead of low-glycemic foods helps overweight people lose more fat and keep more muscle. This finding is from the abstract summary - full study details were not available
Eating fewer carbs and calories helps overweight people lose weight by improving how their bodies process energy. This finding is from the abstract summary - full study details were not available
About 750 million overweight children may develop early signs of diseases like diabetes or heart problems. This finding is from the abstract summary - full study details were not available
Being very overweight is connected to serious health problems like diabetes, heart disease, high blood pressure, and some cancers. This finding is from the abstract summary - full study details were not available
MOTS-c helps slow down a key cellular growth pathway in pancreatic cells.
When stressed, older mice's pancreatic cells have less MOTS-c than younger mice's cells.
MOTS-c helps pancreatic cells produce more energy through their mitochondria.
Pancreatic cells from people with type 2 diabetes have less MOTS-c gene activity than healthy cells.
Adding more MOTS-c to pancreatic cells reduces genes involved in glutamine processing.
MOTS-c helps turn down genes linked to cell aging in pancreatic cells.
MOTS-c helps diabetic mice process sugar better and reduces aging signs in their pancreas cells.
Giving MOTS-c to diabetic mice helps reduce signs of aging in their pancreatic cells.
Older mice have less MOTS-c in their pancreatic cells than younger mice.
People with type 2 diabetes have less MOTS-c in their blood than people without diabetes.
Certain drugs like Metformin might help activate aging-related pathways, and some could work better with exercise, but this is just a theory from the abstract summary - full study details were not available