Can super low cholesterol be safe?
Clinical and pathophysiological evidence supporting the safety of extremely low LDL levels-The zero-LDL hypothesis.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
This study looks at whether having very, very low 'bad' cholesterol (LDL) is safe for people. It checks what happens in people who naturally have super low levels or take strong cholesterol drugs.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 51 / 5
Evidence Score
Based on clinical experience or non-systematic literature reviews. The lowest level of evidence as they are most susceptible to bias and personal perspective.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
This study looks at whether having very, very low 'bad' cholesterol (LDL) is safe for people. It checks what happens in people who naturally have super low levels or take strong cholesterol drugs.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 51 / 5
Evidence Score
Based on clinical experience or non-systematic literature reviews. The lowest level of evidence as they are most susceptible to bias and personal perspective.
Publication
Authors
Masana L, Girona J, Ibarretxe D, Rodríguez-Calvo R, Rosales R, Vallvé JC, Rodríguez-Borjabad C, Guardiola M, Rodríguez M, Guaita-Esteruelas S, Oliva I, Martínez-Micaelo N, Heras M, Ferré R, Ribalta J, Plana N
Related Content
Claims (5)
Really low 'bad' cholesterol might actually be a sign your body is doing a great job cleaning it out — not something to worry about.
Having really low 'bad' cholesterol thanks to how your body naturally processes it doesn’t seem to cause health problems, even over many years.
People who take cholesterol-lowering drugs and get their bad cholesterol really low don’t seem to have more side effects than those who don’t get it as low.
Can someone be perfectly healthy even if their 'bad' cholesterol is super low—like 14 mg/dL?
Your body gets rid of cholesterol mainly through a cleanup system in the liver—since cells can't break cholesterol down, they send it to the liver to be removed.