How a special shot smooths dimpled skin
Collagenase Clostridium histolyticum for the Treatment of Cellulite in the Buttocks and Thigh: Early Insights From Clinical Practice
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
A doctor injects a special enzyme into dimples on the butt and thighs to break the tight strings under the skin that cause the dimples.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
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Evidence Score
Based on clinical experience or non-systematic literature reviews. The lowest level of evidence as they are most susceptible to bias and personal perspective.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
A doctor injects a special enzyme into dimples on the butt and thighs to break the tight strings under the skin that cause the dimples.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 51 / 5
Evidence Score
Based on clinical experience or non-systematic literature reviews. The lowest level of evidence as they are most susceptible to bias and personal perspective.
Publication
Authors
Graivier M, Hill D, Katz B, Boehm KA, Fisher J, Battista C
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Claims (4)
Cellulite is caused by fibrous septae tethering the dermis to underlying fascia, creating dimpling as subcutaneous fat herniates through these structures; enzymatic disruption of these septae can reduce the appearance of cellulite.
The FDA only approved this enzyme injection for the butt, but doctors often use it on the thighs too — with a weaker solution and different injection pattern.
A special enzyme injection breaks up the tough bands under the skin that cause dimples, making the skin look smoother in the butt and thighs.
After getting the cellulite injection, most people get bruises that get less bad with each treatment, but in fair-skinned people, dark spots from bruising can last more than a year.