As we age, levels of a molecule called NAD+ go down, and this might mess up how our cells' powerhouses work, especially in the brain and liver, possibly leading to diseases like Alzheimer's or diabetes.

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Evidence from Studies

Supporting (1)

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Kynurenine pathway, NAD+ synthesis, and mitochondrial function: Targeting tryptophan metabolism to promote longevity and healthspan.

Narrative Review

Animal

2020 Apr

The study shows that as animals age, their NAD+ levels drop, which harms mitochondria and stress defenses—this supports the idea that low NAD+ contributes to aging and disease.

Contradicting (0)

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Kynurenine pathway, NAD+ synthesis, and mitochondrial function: Targeting tryptophan metabolism to promote longevity and healthspan.

Score: 1

DOI: 10.1016/j.exger.2020.110841

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