Giving older mice supplements like NR or NMN might help their energy levels, reduce inflammation, and improve how well their bodies work—but the results aren't the same in every study.

What we've found so far is that the evidence leans toward NR and NMN supplements possibly supporting better health and physical function in aging rodents. Our analysis of the available research shows 28.0 studies indicating these supplements may help improve energy levels, reduce inflammation, and support overall bodily function in older mice [1]. No studies we’ve reviewed have reported opposing results. We looked at a total of one key assertion from the research, and every piece of evidence tied to it supports the idea that NR or NMN could have beneficial effects in aging mice [1]. These supplements are thought to boost levels of NAD+, a molecule involved in energy production and cellular health, which tends to drop as animals age. While the exact effects vary across studies—some mice show stronger improvements than others—the overall pattern we’ve seen so far points in a consistent direction. That said, not every study produces the same results. We’ve noticed differences in outcomes, which could be due to variations in dosage, how long the supplements were given, or the specific strain and age of the mice used. Because of this, we can’t say for sure how strong or predictable the benefits are. Our current analysis doesn’t allow us to claim these supplements always work the same way in all aging rodents. We also want to be clear: our findings are based on a limited number of assertions—just one, in fact—though it draws from 28 supporting studies. This means our understanding is still early and could change as we review more evidence over time. Practical takeaway: In lab mice, NR and NMN might help with age-related decline, but results aren’t guaranteed and can vary.