Eating a breakfast with 30 grams of protein increases satiety hormones but does not lead to eating less at the next meal in healthy adults aged 18–80.
Mechanism
Synthesis from 1 study
Eating protein makes your gut release signals that tell your brain you're full, and you feel less hungry. But your brain doesn't use those signals to stop you from eating more when food is available.
Most probable mechanism
Eating protein triggers the gut to release hormones that signal fullness to the brain, but the brain does not use those signals to reduce how much food is eaten at the next meal.
Amino acids from digested dietary protein reach the distal small intestine and colon.
Amino acids activate G-protein-coupled receptors on enteroendocrine L-cells, triggering intracellular calcium signaling.
L-cells release glucagon-like peptide-1 and peptide YY into the bloodstream.
Circulating glucagon-like peptide-1 and peptide YY bind to receptors on vagal afferent nerves and hypothalamic neurons.
Neural signals from the gut reduce subjective hunger and increase perceived satiety.
Despite elevated satiety signals, the central nervous system does not reduce motor drive to initiate eating during ad libitum food access.
Evidence from Studies
Supporting (1)
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Contradicting (0)
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