MOTS-c changed the activity of genes involved in fat metabolism in the muscles of immobilized mice.
Scientific Claim
RNA sequencing of skeletal muscle from male C57BL/6J mice with 8 days of hindlimb immobilization revealed that daily MOTS-c administration (15 mg/kg/day) was associated with altered expression of genes in the PPAR signaling pathway related to adipogenesis.
Original Statement
“Unbiased RNA sequencing and its downstream analyses demonstrated that MOTS-c modified adipogenesis-modulating gene expression within the peroxisome proliferator-activated receptor (PPAR) pathway.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The claim describes observed gene expression changes without causal language, appropriate for the study's RNA-seq data.
Evidence from Studies
Supporting (1)
Mitochondrial-derived microprotein MOTS-c attenuates immobilization-induced skeletal muscle atrophy by suppressing lipid infiltration.