quantitative
Analysis v1
8
0
Obese mice treated with MOTS-c had lower levels of ANGPTL4 in their muscles, which may help prevent fat buildup.
Scientific Claim
In diet-induced obese mice, MOTS-c injection was associated with reduced ANGPTL4 mRNA expression in skeletal muscle (P < 0.05; n=6 per group).
Original Statement
“ANGPTL4 expression is lower in muscle, but not in other tissues (Figs. 4A–C and Fig. S2A–F). Data are reported as mean ± SEM of six mice per group. *P < 0.05.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study design allows for association claims between treatment and outcome, but lacks randomization and blinding, so causal language is inappropriate. 'Associated with' correctly reflects the evidence.
Evidence from Studies
Supporting (1)
8
Contradicting (0)
0
No contradicting evidence found