MOTS-c increased the production of a protein called ANGPTL4 in the muscles of immobilized mice, which helps control fat uptake into muscle tissue.
Scientific Claim
In male C57BL/6J mice subjected to 8 days of hindlimb cast immobilization, MOTS-c administration (15 mg/kg/day) was associated with higher ANGPTL4 mRNA and protein expression levels in skeletal muscle compared to immobilized control mice.
Original Statement
“The protein expression levels of ANGPTL4, suppressing lipid uptake into tissues by regulating lipoprotein lipase (LPL) activity, were higher in the MOTS-c-treated group than in the immobilization control group (Fig. 5B).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study is an animal cohort with no blinding confirmation, so causal language is inappropriate. The claim uses 'associated with' which correctly reflects the associative evidence.
Evidence from Studies
Supporting (1)
Mitochondrial-derived microprotein MOTS-c attenuates immobilization-induced skeletal muscle atrophy by suppressing lipid infiltration.