MOTS-c changed the activity of genes related to fat metabolism and PPAR pathways in the muscles of immobilized mice, which may affect how fat builds up in muscle tissue.

MOTS-c changed the activity of genes involved in fat metabolism in the muscles of immobilized mice.

Mice given MOTS-c had more ANGPTL4 protein in their muscles and less fatty acids, which may help prevent muscle damage from fat buildup.

MOTS-c reduced the amount of fatty acids in the muscles of immobilized mice, which may prevent harmful fat buildup.

MOTS-c lowered levels of myostatin, a protein that inhibits muscle growth, in the muscles of immobilized mice.

MOTS-c increased the production of a protein called ANGPTL4 in the muscles of immobilized mice, which helps control fat uptake into muscle tissue.