NAC reduces TNF-alpha, an inflammatory molecule that causes insulin resistance, which helps the body's metabolism work better.
Scientific Claim
N-acetylcysteine suppresses TNF-alpha production in immune cells by approximately 56%, which mitigates obesity-induced insulin resistance by disrupting the inflammatory signaling pathway that impairs metabolic function.
Original Statement
“There was a study that was published in sarcoidosis vasculitis and diffuse lung disease that showed that NAC suppressed TNF alpha by roughly 56% in immune cells. TNF alpha is a key inflammatory cytoine when you're talking about like obesity induced insulin resistance. There was a classic study that was in nature that showed that mice that were lacking TNF uh signaling were protected from insulin resistance and metabolic dysfunction. So if they knocked that out where that whole cytoine wasn't effective, it didn't have the same metabolic effect. So when NAC lowers this inflammatory cytoine, it's not just calming inflammation, it's restoring metabolic communication.”
Context Details
Domain
pharmacology
Population
mixed
Subject
N-acetylcysteine (NAC)
Action
suppresses
Target
TNF-alpha production in immune cells by approximately 56%, mitigating obesity-induced insulin resistance
Intervention Details
Evidence from Studies
Supporting (1)
N-acetylcysteine Protects Mice from High Fat Diet-induced Metabolic Disorders