People in Japan between 22 and 59 years old took a daily supplement of hyaluronan for 12 weeks and didn’t feel any bad side effects—so it seems safe for them to take it this way for a short time.

Taking a daily supplement of hyaluronan for 3 months may make your skin look shinier and feel softer, at least according to how people felt about it — but it didn’t work any better than a fake pill.

People who took a specific type of hyaluronic acid supplement every day for 3 months didn’t show a clear improvement in crow’s feet wrinkles, but there was a tiny hint that it might help—just not enough to be sure.

If you give female mice a special kind of hyaluronic acid pill every day for a week, their bodies end up with more of this substance in their blood and several organs like their skin, eyes, and bladder.

Taking a daily supplement of hyaluronan for 12 weeks can make your skin feel tighter and more bouncy on your forehead, arms, and waist—especially at your waist, where it improved by 38% compared to people who didn’t take it.

Giving mice a specific type of hyaluronic acid pill every day for a week doesn't make more of it show up in their blood or body tissues compared to mice that just got water.