Can swallowing jelly help smooth wrinkles?
Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
People took a daily jelly-like supplement called hyaluronan to see if it made wrinkles around their eyes go away.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 560 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
People took a daily jelly-like supplement called hyaluronan to see if it made wrinkles around their eyes go away.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 560 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Publication
Authors
Oe M, Sakai S, Yoshida H, Okado N, Kaneda H, Masuda Y, Urushibata O
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Claims (5)
Taking a specific type of hyaluronic acid pill every day for 3 months can noticeably reduce the wrinkles around your eyes, according to a study where people who took it had 22% fewer wrinkles than those who took a fake pill.
People in Japan between 22 and 59 years old took a daily supplement of hyaluronan for 12 weeks and didn’t feel any bad side effects—so it seems safe for them to take it this way for a short time.
Taking a daily supplement of hyaluronan for 3 months may make your skin look shinier and feel softer, at least according to how people felt about it — but it didn’t work any better than a fake pill.
People who took a specific type of hyaluronic acid supplement every day for 3 months didn’t show a clear improvement in crow’s feet wrinkles, but there was a tiny hint that it might help—just not enough to be sure.
People in every group—even those who got a fake treatment—said their wrinkles looked better after 8 or 12 weeks, which suggests that the improvement might just be in their heads or because of the season, not because of the actual skin product they used.