People who took a specific type of hyaluronic acid supplement every day for 3 months didn’t show a clear improvement in crow’s feet wrinkles, but there was a tiny hint that it might help—just not...

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Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period

Randomized Controlled Trial

Human

2017

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period

Score: 60

DOI: 10.2147/ccid.s141845

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