People who took a specific type of hyaluronic acid supplement every day for 3 months didn’t show a clear improvement in crow’s feet wrinkles, but there was a tiny hint that it might help—just not enough to be sure.
Claim Language
Language Strength
probability
Uses probability language (may, likely, can)
The claim uses 'shows a non-significant trend toward' which indicates uncertainty and likelihood rather than certainty. The phrase 'trend toward' implies a possible effect that is not confirmed, and 'non-significant' with a p-value of 0.052 reinforces probabilistic language rather than definitive conclusions.
Context Details
Domain
medicine
Population
human
Subject
Healthy Japanese adults aged 22–59
Action
shows
Target
a non-significant trend toward reducing crow’s feet wrinkles
Intervention Details
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.
Evidence from Studies
Supporting (0)
Contradicting (1)
Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period
The study gave people two types of hyaluronan pills — one was 2 kDa like the claim, but the results for that one weren’t clearly shown to help wrinkles much, while the other type (300 kDa) did work better. So it doesn’t back up the claim about the 2 kDa version.