Taking hyaluronan pills every day for about a month or two may help make dry skin on your face and arms more moisturized, according to studies done on Japanese adults.

In Japanese adults with clinically diagnosed dry skin, participants receive either 120–240 mg/day of oral hyaluronan or a matching placebo for 4–6 weeks, with skin moisture measured by Corneometer® at baseline, week 2, week 4, and week 6 in both facial and arm regions.

A systematic review identifying all published randomized, double-blind, placebo-controlled trials in Japanese adults with dry skin that tested oral hyaluronan (120–240 mg/day) for 4–6 weeks and reported Corneometer® skin moisture outcomes in facial and arm regions, with pooled effect size analysis.

A parallel-group RCT in Japanese adults with dry skin comparing 120 mg/day vs. 240 mg/day hyaluronan vs. placebo over 6 weeks, measuring Corneometer® skin moisture at baseline and weekly, with follow-up at 2 weeks post-intervention to assess persistence of effect.

A single-center RCT in Japan using standardized diagnostic criteria for dry skin, standardized Corneometer® measurement protocols on facial and arm sites, and consistent hyaluronan formulation (120–240 mg/day) over 4–6 weeks, with blinding confirmed and adherence monitored.

An observational cohort study in Japanese adults with dry skin comparing those who self-reported daily hyaluronan intake (120–240 mg/day) for 4–6 weeks with matched controls, measuring Corneometer® skin moisture at baseline and endpoint, adjusting for confounders like humidity, skincare routines, and age.