Scientists don’t know enough about how the whole mix of small and big fat cells works together to affect health.

Reduction in adipose tissue volume is accompanied by increased adipocyte density, reflecting smaller adipocyte size, improved vascularization, reduced hypoxia, and decreased local inflammation.

Making big fat cells smaller by eating less, moving more, or having weight-loss surgery helps fat cells work better and improves your health.

When your body has extra energy, it stores it in fat cells by making the cells bigger or making more of them.

When fat cells get too big, they don't work well and the body tries to stop them from growing further to avoid damage and swelling.