The fat cells don’t just get smaller—they get healthier, with better oxygen and less swelling.
Scientific Claim
Reduction in adipose tissue volume is accompanied by increased adipocyte density, reflecting smaller adipocyte size, improved vascularization, reduced hypoxia, and decreased local inflammation.
Original Statement
“tessamellin independently increased fat density. That means the fat tissue itself became healthier, smaller fat cells, you have better blood supply, uh less hypoxia and less inflammation in the actual fat cell.”
Context Details
Domain
pharmacology
Population
human
Subject
Tesamorelin
Action
increases adipose tissue density
Target
reflecting healthier adipocyte morphology and reduced inflammation
Intervention Details
Evidence from Studies
Supporting (2)
Tesamorelin improves fat quality independent of changes in fat quantity
When people took a drug that reduced belly fat, the remaining fat cells got smaller and healthier — like shrinking a balloon to make it tighter and better functioning — even though there was less fat overall.
Adipose cell size: importance in health and disease.
When fat cells get too big, they get sick and cause inflammation; making them smaller again—through diet or exercise—helps them work better and reduces body inflammation.
Contradicting (1)
Even when people lost belly fat by eating fewer calories, their fat cells didn’t get smaller or less inflamed — and dairy didn’t change that. So the idea that losing fat automatically makes fat cells healthier isn’t supported by this study.