The fat directly on the heart makes more harmful molecules than the fat around the big blood vessels, even without any treatment.
Scientific Claim
Human epicardial adipose tissue produces higher levels of reactive oxygen species than perivascular adipose tissue under baseline conditions, as measured by dihydroethidium fluorescence and FOX assay in tissue samples from 25 patients with heart failure.
Original Statement
“As showed in Fig. 3, a higher intensity of the DHE stain (arbitrary units) was present in EAT as compared to PVAT, a result that recapitulates the observation on MAOs expression in the two types of adipose tissues presented in Fig. 1.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
The claim is a direct comparison of baseline ROS levels between two tissue types measured in the same experimental setup. No causal or clinical inference is made, so definitive language is appropriate.
Evidence from Studies
Supporting (0)
Contradicting (1)
Methylene blue reduces monoamine oxidase expression and oxidative stress in human cardiovascular adipose tissue
The study looked at two types of fat around the heart and found both make harmful molecules called ROS, but it never compared which one makes more under normal conditions, so we can’t say if the claim is true or false.