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Strong Support

The fat directly on the heart makes more harmful chemicals than the fat around blood vessels, and this matches with it having more of the enzyme MAO-A.

33
Pro
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Against

Evidence from Studies

Supporting (1)

33

Community contributions welcome

33

Methylene blue reduces monoamine oxidase expression and oxidative stress in human cardiovascular adipose tissue

Cross-Sectional Study
Human
2025 Apr

The study found that a specific enzyme (MAO-A) in heart fat makes harmful molecules called ROS, and this enzyme is especially active in the fat around the heart — which matches the claim that this fat makes more ROS because it has more of this enzyme.

Contradicting (0)

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No contradicting evidence found

Source Study

Methylene blue reduces monoamine oxidase expression and oxidative stress in human cardiovascular adipose tissue

Score: 33
DOI: 10.1007/s11010-024-05092-z

Similar Assertions

The fat directly on the heart makes more harmful molecules than the fat around the big blood vessels, even without any treatment.

0
33
78%

When fat tissue around the heart and blood vessels was soaked in a blue dye called methylene blue for a day in the lab, it made less of a harmful enzyme and produced fewer damaging chemicals, which might help explain how the dye could protect cells.

33
0
75%

When the fat tissue was given serotonin (a chemical that MAO-A breaks down), it made more harmful molecules—but adding methylene blue stopped some of that increase.

33
0
74%

In the fat around the heart and blood vessels of heart failure patients, a specific enzyme called MAO-A is much more common and makes more harmful chemicals than its cousin MAO-B.

33
0
71%