Taking a specific supplement called sodium hyaluronate every day for 3 months may boost a natural skin moisturizer called PCA, which could help your skin stay more hydrated.
Claim Language
Language Strength
definitive
Uses definitive language (causes, prevents, cures)
The claim uses the verb 'causes,' which implies a direct and deterministic effect, not just a possibility or association. This is a strong causal language indicating the intervention directly produces the outcome.
Context Details
Domain
medicine
Population
human
Subject
Oral sodium hyaluronate (120 mg/day for 12 weeks)
Action
causes
Target
a significant increase in pyrrolidone carboxylic acid (PCA) levels in the stratum corneum of healthy Caucasian adults
Intervention Details
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.
Evidence from Studies
Supporting (1)
Oral sodium hyaluronate improves skin hydration, barrier function and signs of aging: a randomized, double-blind, placebo-controlled trial in 150 healthy adults
The study gave people 120 mg of sodium hyaluronate daily for 12 weeks and found their skin’s natural moisturizing stuff increased — and PCA is one of the main parts of that stuff, so yes, it likely went up too.