Can a pill make your skin plumper and smoother?
Oral sodium hyaluronate improves skin hydration, barrier function and signs of aging: a randomized, double-blind, placebo-controlled trial in 150 healthy adults
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Oral sodium hyaluronate increased epidermal thickness and dermal density—meaning it actually rebuilt skin structure, not just hydrated the surface.
Most people assume oral supplements just circulate and get broken down—this suggests HA molecules or their fragments signal skin cells to rebuild collagen and thicken layers.
Practical Takeaways
Try a 120 mg/day sodium hyaluronate supplement for 12 weeks if you have dry skin or fine lines—look for 1.8 MDa molecular weight.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Oral sodium hyaluronate increased epidermal thickness and dermal density—meaning it actually rebuilt skin structure, not just hydrated the surface.
Most people assume oral supplements just circulate and get broken down—this suggests HA molecules or their fragments signal skin cells to rebuild collagen and thicken layers.
Practical Takeaways
Try a 120 mg/day sodium hyaluronate supplement for 12 weeks if you have dry skin or fine lines—look for 1.8 MDa molecular weight.
Publication
Journal
Scientific Reports
Year
2025
Authors
I. Dolečková, Pavel Kušnierik, Vratislav Berka, Matěj Šimek, Ilona Matějková, Filip Prokopec, Petra Ovesná
Related Content
Claims (7)
Taking a daily supplement of sodium hyaluronate for 12 weeks can make your cheeks 11.5% and forehead 7.2% more hydrated, and your skin looks and feels healthier.
Taking a daily supplement of sodium hyaluronate for 3 months may help keep older people’s skin thicker and more youthful by slowing down the natural thinning of skin layers and protecting the collagen that gives skin its structure.
Taking a daily supplement of sodium hyaluronate for 3 months can help your skin hold onto more moisture, especially on your cheeks and forehead, making your skin barrier stronger.
Taking a daily supplement of sodium hyaluronate for 3 months can make the fine lines around your eyes noticeably smoother—by about 1 in 8 to 1 in 7—starting as soon as one month in.
Taking a specific supplement called sodium hyaluronate every day for 3 months may boost a natural skin moisturizer called PCA, which could help your skin stay more hydrated.