Taking a daily supplement of sodium hyaluronate for 3 months can help your skin hold onto more moisture, especially on your cheeks and forehead, making your skin barrier stronger.
Claim Language
Language Strength
definitive
Uses definitive language (causes, prevents, cures)
The claim uses the verb 'causes', which implies a direct and certain causal relationship between the intervention (oral sodium hyaluronate) and the outcome (reduction in TEWL), without hedging or probabilistic language.
Context Details
Domain
medicine
Population
human
Subject
Oral sodium hyaluronate (120 mg/day for 12 weeks)
Action
causes
Target
a significant reduction in transepidermal water loss (TEWL) by 15–20% on the cheek and forehead in healthy Caucasian adults, indicating enhanced skin barrier function
Intervention Details
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.
Evidence from Studies
Supporting (1)
Oral sodium hyaluronate improves skin hydration, barrier function and signs of aging: a randomized, double-blind, placebo-controlled trial in 150 healthy adults
This study gave people 120 mg of sodium hyaluronate daily for 12 weeks and found their skin lost less water, meaning their skin barrier got stronger — just like the claim says.