Taking a daily supplement of hyaluronan for 12 weeks can help your skin hold onto more moisture, making your face less dry — like a natural moisture lock.
Claim Language
Language Strength
definitive
Uses definitive language (causes, prevents, cures)
The claim uses 'significantly reduces' — a definitive verb phrase that implies a direct, measurable, and causal effect, not a possibility or correlation.
Context Details
Domain
medicine
Population
human
Subject
Healthy Asian adults aged 35–64
Action
reduces
Target
transepidermal water loss (TEWL) by 15.6% on the face
Intervention Details
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.
Evidence from Studies
Supporting (1)
Oral Hyaluronan Relieves Wrinkles and Improves Dry Skin: A 12-Week Double-Blinded, Placebo-Controlled Study
This study gave people 120 mg of hyaluronan daily for 12 weeks and found their skin lost less water, meaning their skin barrier got stronger — exactly what the claim says.