Can swallowing a pill make your skin smoother?
Oral Hyaluronan Relieves Wrinkles and Improves Dry Skin: A 12-Week Double-Blinded, Placebo-Controlled Study
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
People took a daily pill with a substance found in skin, and after 3 months, their skin got more hydrated, less wrinkled, and more bouncy.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 559 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
People took a daily pill with a substance found in skin, and after 3 months, their skin got more hydrated, less wrinkled, and more bouncy.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 559 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Publication
Authors
Hsu TF, Su ZR, Hsieh YH, Wang MF, Oe M, Matsuoka R, Masuda Y
Related Content
Claims (6)
Taking a daily supplement of sodium hyaluronate for 3 months can make your face skin noticeably more hydrated—about 11.5% more—than if you didn’t take it.
Taking a daily supplement of hyaluronan for 12 weeks can make your face more hydrated, with a noticeable 10.9% boost in skin moisture compared to not taking it—this also helps your skin stay protected and lose less water.
Taking a daily supplement of hyaluronan for 12 weeks can make your skin feel tighter and more bouncy on your forehead, arms, and waist—especially at your waist, where it improved by 38% compared to people who didn’t take it.
Taking a daily supplement of hyaluronan for 12 weeks can make your facial wrinkles look about 11.5% less noticeable, compared to not taking anything, if you're a healthy Asian adult between 35 and 64.
Taking a daily supplement of hyaluronan for 12 weeks can help your skin hold onto more moisture, making your face less dry — like a natural moisture lock.